Human PER1(Period Circadian Protein 1) ELISA Kit

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Period Circadian Protein 1 (PER1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Period Circadian Protein 1 (PER1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Period Circadian Protein 1 (PER1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Period Circadian Protein 1 (PER1) in Tissue homogenates, cell lysates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Period Circadian Protein 1 (PER1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Description: Recombinant Human Period Circadian Protein 1 expressed in: E.coli

Description: A sandwich ELISA kit for detection of Period Circadian Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Description: A Rabbit polyclonal antibody against Human Period Circadian Protein 1 (PER1)

Description: Quantitative sandwich ELISA for measuring Human Period circadian protein homolog 1 (PER1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Period circadian protein homolog 1 (PER1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Period circadian protein homolog 1 (PER1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Period Circadian Protein 1 (PER1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Period Circadian Protein 1 (PER1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Period Circadian Protein 1 (PER1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Period Circadian Protein 1 (PER1) in Tissue homogenates, cell lysates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of High Sensitive Period Circadian Protein 1 (PER1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Description: A Rabbit polyclonal antibody against Human Period Circadian Protein 1 (PER1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Period Circadian Protein 1 (PER1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Period Circadian Protein 1 (PER1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Period Circadian Protein 1 (PER1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Period Circadian Protein 1 (PER1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Period Circadian Protein 1 (PER1). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human Period Circadian Protein 1 (PER1). This antibody is labeled with APC-Cy7.

Description: A sandwich quantitative ELISA assay kit for detection of Rat Period Circadian Protein 2 (PER2) in samples from tissue homogenates or other biological fluids.

Description: A sandwich quantitative ELISA assay kit for detection of Rat Period Circadian Protein 2 (PER2) in samples from tissue homogenates or other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Period Circadian Protein 2 (PER2) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Period Circadian Protein 2 (PER2) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Period Circadian Protein 2 (PER2) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Period Circadian Protein 2 (PER2) in Tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Period Circadian Protein 2 (PER2) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Description: Recombinant Rat Period Circadian Protein 2 expressed in: E.coli

Description: A sandwich ELISA kit for detection of Period Circadian Protein 2 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Period circadian protein homolog 2 (PER2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Period circadian protein homolog 2 (PER2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Period circadian protein homolog 2 (PER2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: A Rabbit polyclonal antibody against Rat Period Circadian Protein 2 (PER2)

Description: A Rabbit polyclonal antibody against Rat Period Circadian Protein 2 (PER2). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Rat Period Circadian Protein 2 (PER2). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Rat Period Circadian Protein 2 (PER2). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Rat Period Circadian Protein 2 (PER2). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Rat Period Circadian Protein 2 (PER2). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Rat Period Circadian Protein 2 (PER2). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Rat Period Circadian Protein 2 (PER2). This antibody is labeled with APC-Cy7.

Description: Description of target: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.24"A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock."_x005F_x005F_x000D_Al-Nuaimi Y., Hardman J.A., Biro T., Haslam I.S., Philpott M.P., Toth B.I., Farjo N., Farjo B., Baier G., Watson R.E., Grimaldi B., Kloepper J.E., Paus R._x005F_x005F_x000D_J. Invest. Dermatol. 134:610-619(2014) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN HAIR GROWTH, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.122 ng/mL

Description: Description of target: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.89ng/mL

Description: A polyclonal antibody against PER1. Recognizes PER1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF

Description: A polyclonal antibody against PER1. Recognizes PER1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Description: Rabbit polyclonal PER1 antibody

Description: Mouse monoclonal PER1 antibody

Description: Mouse polyclonal to PER1

Description: A polyclonal antibody against PER1. Recognizes PER1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against PER1. Recognizes PER1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against PER1. Recognizes PER1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: A sandwich ELISA for quantitative measurement of Human Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Human Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Human Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in tissue homogenates, cell lysates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Description: A sandwich ELISA kit for detection of Circadian Locomoter Output Cycles Protein Kaput from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: A cloning plasmid for the PER1 gene.

Description: A cloning plasmid for the PER1 gene.

Description: Antibody raised against PER1

Description: A Rabbit Polyclonal antibody against PER1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Description: A Rabbit Polyclonal antibody against PER1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Description: A polyclonal antibody for detection of PER1 from Human, Mouse, Rat. This PER1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PER1 protein at amino acid sequence of 1110-1190

Description: A polyclonal antibody for detection of PER1 from Human, Mouse, Rat. This PER1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PER1 protein at amino acid sequence of 1110-1190

Description: A polyclonal antibody for detection of PER1 from Human, Mouse, Rat. This PER1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PER1 protein at amino acid sequence of 1110-1190

Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.

Description: Unconjugated Rabbit polyclonal to PER1

Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Description: A sandwich ELISA for quantitative measurement of Porcine Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Porcine Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Porcine Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Goat Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Goat Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Goat Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Canine Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Canine Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Canine Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Monkey Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Monkey Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Monkey Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Rabbit Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Rabbit Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Rabbit Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Rat Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Rat Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Rat Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Mouse Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Mouse Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: A sandwich ELISA for quantitative measurement of Mouse Circadian locomoter output cycles protein kaput(CLOCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Circadian Locomoter Output Cycles Protein Kaput (CLOCK) in Tissue homogenates, cell lysates and other biological fluids.