Plain English summary
A small medical school research project entitled ‘PPI to strengthen clinical and population health research’ caused me to look at an entirely new field – that of Public and Patient Involvement (PPI). PPI is the development of an active partnership between patients and the public and researchers to work alongside each other not just during trial participation but, at each research step.
Internet research and use of materials supplied by my tutors changed my understanding and appreciation for the field of PPI. Coming across the story surrounding gay rights campaigners and development of early PPI inspired me to investigate how it is used it modern studies. It struck me how despite its importance, PPI often went undiscussed in contemporary studies.
However, one study named PROUD used and reported PPI in an exemplary fashion in order to combat issues and strengthen the trial. PROUD’s PPI improved study design, safety and advertising as well as providing reassurance in difficult times. It also improved recruitment, dissemination of information and made sure that results and future research fields were relevant.
Through PROUD and also my own experiences working with a PPI group I was able to develop an understanding and appreciation for the importance PPI. I write with hope to make my learning available to others.
Abstract
A research project during my third year at medical school introduced me to PPI. PPI is defined as research carried out with or by members of the public rather than to, about or for them. Historical gay rights activists’ involvement in research catalysed developments in PPI before it was widely recognised. A contemporary study, PROUD, used exemplary PPI contributions to tackle these issues and make the study successful.
My research project was entitled ‘How did PPI contribute towards the PROUD study & what can be learnt from this?’. This letter aims to answer this question but also include my personal reflections on my work and how I developed an understanding and appreciation for the importance PPI. PubMed and Google were examined, as well as University resources.
Nitromethane 95% |
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| N09630 | Pfaltz & Bauer | 1L | 528.12 EUR |
Nitromethane - 1ML |
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| S-2722 | Scientific Laboratory Supplies | 1ML | 103.95 EUR |
Nitromethane ACS, 98% |
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| 20509 | Sisco Laboratories | 500 ml | 7.25 EUR |
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Description: Part A |
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250 ug/mL Nitromethane in DMSO - 1ML |
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| USP-S2722-DMSO | Scientific Laboratory Supplies | 1ML | 122.85 EUR |
Beta-D-Glucopyranosyl nitromethane |
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| T40926-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Beta-D-Glucopyranosyl nitromethane |
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Beta-D-Glucopyranosyl nitromethane |
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| T40926-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Beta-D-Glucopyranosyl nitromethane |
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Beta-D-Glucopyranosyl nitromethane |
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| T40926-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Beta-D-Glucopyranosyl nitromethane |
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Beta-D-Glucopyranosyl nitromethane |
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| T40926-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Beta-D-Glucopyranosyl nitromethane |
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Beta-D-Glucopyranosyl nitromethane |
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| T40926-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Beta-D-Glucopyranosyl nitromethane |
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Beta-D-Glucopyranosyl nitromethane |
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| MBS5801080-100mg | MyBiosource | 100(mg | 180 EUR |
Beta-D-Glucopyranosyl nitromethane |
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| MBS5801080-50mg | MyBiosource | 50(mg | 150 EUR |
Beta-D-Glucopyranosyl nitromethane |
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| MBS5801080-5x100mg | MyBiosource | 5x100(mg | 665 EUR |
Beta-D-Glucopyranosyl nitromethane |
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| HY-141490 | MedChemExpress | 10 mg | 183.99 EUR |
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Description: Beta-D-Glucopyranosyl nitromethane, as a salt of a strongly basic anion exchanger in the OH cycle, is a glycosyl derivative of nitromethane[1]. |
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1,1-Dichloroethane (Stabilized with Nitromethane, ~0.5%) (>90%) |
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| D434245 | Toronto Research Chemicals | 10g | 288 EUR |
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Description: 75-34-3 |
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2'-(4-Methoxyphenoxy)-4'-nitromethanesulfonanilide |
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| M265735 | Toronto Research Chemicals | 100mg | 2082 EUR |
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Description: 51765-76-5 |
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4-Nitro-2-(nitromethyl)phenol |
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| N456210 | Toronto Research Chemicals | 1g | 800 EUR |
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Description: 36363-18-5 |
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3-Nitro-4-methylphenol |
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Description: 2042-14-0 |
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3-Nitro-4-methylphenol |
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| MBS6099424-10g | MyBiosource | 10g | 505 EUR |
3-Nitro-4-methylphenol |
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| MBS6099424-1g | MyBiosource | 1(g | 395 EUR |
3-Nitro-4-methylphenol |
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3-Nitro-4-methylphenol |
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3-Nitro-4-methylphenol |
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| MBS6099424-5x50g | MyBiosource | 5x50g | 3725 EUR |
3-Nitromethylphthalide |
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3-Nitromethylphthalide |
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1-Nitromethylcyclohexanol |
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2-Nitro-3-methyl-9H-pyrido[2,3-b]indole |
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| N493980 | Toronto Research Chemicals | 250mg | 9200 EUR |
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Description: 186527-30-0 |
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3-Nitro-1-methyl-5H-pyrido[4,3-b]indole |
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| N493985 | Toronto Research Chemicals | 25mg | 800 EUR |
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Description: 75567-58-7 |
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2-Nitro-3-methyl-9H-pyrido[2,3-b]indole |
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| MBS6050140-25mg | MyBiosource | 2.5(mg | 610 EUR |
2-Nitro-3-methyl-9H-pyrido[2,3-b]indole |
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| MBS6050140-5x25mg | MyBiosource | 5x2.5mg | 2600 EUR |
3-Nitro-1-methyl-5H-pyrido[4,3-b]indole |
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3-Nitro-1-methyl-5H-pyrido[4,3-b]indole |
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| MBS6040937-5x25mg | MyBiosource | 5x2.5mg | 2600 EUR |
5-Methyl-3-(nitromethyl)hex-4-enoic Acid |
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| M340388 | Toronto Research Chemicals | 100mg | 1800 EUR |
3-Nitro-4-Methoxybenzoic Acid 98% _x000D_ |
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| N09700 | Pfaltz & Bauer | 25G | 65.6 EUR |
4-Nitro-4-Methylvaleronitrile |
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| N09990 | Pfaltz & Bauer | 1G | 322.7 EUR |
1-Bromo-4-[(nitromethyl)sulfonyl]benzene |
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| B233370 | Toronto Research Chemicals | 1g | 1200 EUR |
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Description: 122263-08-5 |
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3-Nitro-4-toluidine (3-Nitro-4-methylaniline) |
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| MBS6061424-5g | MyBiosource | 5(g | 505 EUR |
3-Nitro-4-toluidine (3-Nitro-4-methylaniline) |
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| MBS6061424-5x5g | MyBiosource | 5x5g | 2125 EUR |
5-Nitro-6-methylaminoquinoline |
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| N496575 | Toronto Research Chemicals | 100mg | 259 EUR |
8-Nitro-7-methylaminoquinoline |
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| N496580 | Toronto Research Chemicals | 100mg | 115 EUR |
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Description: 147293-16-1 |
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6-Nitro-5-methylaminoquinoline |
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6-Nitro-5-methylaminoquinoline |
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5-Nitro-6-methylaminoquinoline |
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| MBS6096149-250mg | MyBiosource | 250(mg | 485 EUR |
5-Nitro-6-methylaminoquinoline |
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8-Nitro-7-methylaminoquinoline |
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8-Nitro-7-methylaminoquinoline |
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| MBS6068578-5x100mg | MyBiosource | 5x100mg | 2125 EUR |
2-Nitro-6-methyldipyrido[1,2-a:3',2'-d]imidazole |
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Description: 83692-82-4 |
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2-Nitro-6-methyldipyrido[1,2-a:3',2'-d]imidazole |
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2-Nitro-6-methyldipyrido[1,2-a:3',2'-d]imidazole |
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| MBS6063353-5x25mg | MyBiosource | 5x2.5mg | 2600 EUR |
2-Nitro-3-methoxybenzoic acid 97%_x000D__x000D_ |
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| N09690 | Pfaltz & Bauer | 1G | 140.97 EUR |
5-Nitro-6-methylaminoquinoline-d3 |
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| N496577 | Toronto Research Chemicals | 100mg | 173 EUR |
3-Nitro-4-Methoxybenzotrifluoride |
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| N09720 | Pfaltz & Bauer | 25G | 117.73 EUR |
5-Methyl-3-(nitromethyl)hexanoic Acid Ethyl Ester |
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| M324440 | Toronto Research Chemicals | 100mg | 138 EUR |
4-Nitro-4-methylpentanoic acid methyl ester 96% |
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| N09910 | Pfaltz & Bauer | 1G | 291 EUR |
N,N-Diethyl-5-methyl-3-(nitromethyl)hexanamide |
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| D444565 | Toronto Research Chemicals | 100mg | 110 EUR |
3-(Nitromethyl)-5-methyl-4-hexenoic Acid Ethyl Ester |
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| N496610 | Toronto Research Chemicals | 500mg | 173 EUR |
b-(Nitromethyl)benzenepropanoic Acid Methyl Ester |
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| N496595 | Toronto Research Chemicals | 10g | 943 EUR |
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Description: 34687-03-1 |
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1-(Nitromethyl)cyclohexaneacetic Acid Ethyl Ester |
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| MBS6110731-25mg | MyBiosource | 25(mg | 505 EUR |
1-(Nitromethyl)cyclohexaneacetic Acid Ethyl Ester |
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| MBS6110731-5x25mg | MyBiosource | 5x25mg | 2125 EUR |
1-(Nitromethyl)cyclohexaneacetic Acid-d4 Methyl Ester |
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| MBS6082592-1mg | MyBiosource | 1(mg | 510 EUR |
1-(Nitromethyl)cyclohexaneacetic Acid-d4 Methyl Ester |
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| MBS6082592-5x1mg | MyBiosource | 5x1mg | 2145 EUR |
4-nitro-5-methyl-6-methyl-2,1,3-benzoselenodiazole |
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4-nitro-5-methyl-6-methyl-2,1,3-benzoselenodiazole |
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| MBS6088760-5x25mg | MyBiosource | 5x25mg | 2025 EUR |
7-Chloro-2-(nitromethylene)-5-phenyl-3H-1,4-benzodiazepine |
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| C381010 | Toronto Research Chemicals | 1mg | 656 EUR |
2-Chloro-5-[[2-(nitromethylene)-1-imidazolidinyl]methyl]pyridine |
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| C374135 | Toronto Research Chemicals | 250mg | 1200 EUR |
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Description: 101336-63-4 |
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2,3-Dideoxy-4,5-O-(1-methylethylidene)-3-(nitromethyl)-L-threo-pentonic Acid Ethyl Ester |
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| D440105 | Toronto Research Chemicals | 2.5g | 4500 EUR |
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Description: 501921-23-9 |
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17Beta-Hydroxy-17-Alpha-methyl-1-(nitromethyl)-5Alpha-androstan-3-one |
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| H950255 | Toronto Research Chemicals | 10mg | 121 EUR |
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Description: 5823-88-1 |
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7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine |
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| C365270 | Toronto Research Chemicals | 250mg | 161 EUR |
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Description: 59467-63-9 |
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7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine-13C1 |
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| C365272 | Toronto Research Chemicals | 2.5mg | 1344 EUR |
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Description: 1185236-35-4 |
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"7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethylene-2H-1,4-benzodiazepine 4-Oxide" |
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| C366465 | Toronto Research Chemicals | 100mg | 184 EUR |
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Description: 60656-76-0 |
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N-(4-Methyl-3-nitrophenyl)-4-(4-methylpiperazinomethyl)benzamide (N-(3-Nitro-4-methyl-phenyl)-4-(4-methyl-piperazin-1-yl)-benzamide) |
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| MBS6057602-10mg | MyBiosource | 10(mg | 485 EUR |
N-(4-Methyl-3-nitrophenyl)-4-(4-methylpiperazinomethyl)benzamide (N-(3-Nitro-4-methyl-phenyl)-4-(4-methyl-piperazin-1-yl)-benzamide) |
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| MBS6057602-5x10mg | MyBiosource | 5x10mg | 2025 EUR |
2-Nitromesitylene_x000D__x000D_ |
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| N09620 | Pfaltz & Bauer | 10G | 365.12 EUR |
SDS |
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| CSB-CL020926HU | Cusabio | 10 μg plasmid + 200μl Glycerol | Ask for price |
SDS |
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SDS |
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SDS |
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SDS 100.0mM |
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SDS 100.0mM |
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SDS 100.0mM |
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SDS (untagged)-Human serine dehydratase (SDS) |
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| SC115837 | Origene Technologies GmbH | 10 µg | Ask for price |
SDS, 20% |
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Description: Liquid Solution |
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SDS, 20% |
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Description: Liquid Solution |
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SDS 10% |
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SDS 10% |
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SDS 10% |
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SDS 10% |
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20% SDS |
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| CH100 | ABM | 500 ml | 65 EUR |
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Description: SDS is used as a component in PAGE, nucleic acid, hybridization, cell disruption and has many other uses in the lab. |
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20% SDS |
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| ML007-100ML | EWC Diagnostics | 1 unit | 18.24 EUR |
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Description: 20% SDS |
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20% SDS |
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| ML007-500ML | EWC Diagnostics | 1 unit | 76.03 EUR |
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Description: 20% SDS |
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10% SDS |
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| GP003-100mL | Shanghai WSHT Biotechnology | 100mL | 4.2 EUR |
10% SDS |
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| GP003-500mL | Shanghai WSHT Biotechnology | 500mL | 15 EUR |
10% SDS |
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| TG4060 | TopoGen | 1ml | 160.8 EUR |
10% SDS |
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| MBS355537-100mL | MyBiosource | 100mL | 165 EUR |
10% SDS |
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| MBS355537-5x100mL | MyBiosource | 5x100mL | 445 EUR |
10% SDS |
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| S100 | Ecotech Biotechnology | 100 ml | 11 EUR |
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Description: ClearBand 10% SDS (10% w/v) is sodium dodecyl sulfate prepared in 18 MΩ water. SDS is a detergent that is used for denaturation of proteins especially in polyacrylamide gel electrophoresis applications. |
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20% SDS |
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| S100/20 | Ecotech Biotechnology | 100 ml | 16.5 EUR |
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Description: ClearBand 20% SDS (20% w/v) is sodium dodecyl sulfate prepared in 18 MΩ water. SDS is a detergent that is used for denaturation of proteins especially in polyacrylamide gel electrophoresis applications. |
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10% SDS |
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| S500 | Ecotech Biotechnology | 500 ml | 29.7 EUR |
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Description: ClearBand 10% SDS (10% w/v) is sodium dodecyl sulfate prepared in 18 MΩ water. SDS is a detergent that is used for denaturation of proteins especially in polyacrylamide gel electrophoresis applications. |
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20% SDS |
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| S500/20 | Ecotech Biotechnology | 500 ml | 46.2 EUR |
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Description: ClearBand 20% SDS (20% w/v) is sodium dodecyl sulfate prepared in 18 MΩ water. SDS is a detergent that is used for denaturation of proteins especially in polyacrylamide gel electrophoresis applications. |
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SDS siRNA |
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| 20-abx932743 | Abbexa |
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SDS siRNA |
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| 20-abx932744 | Abbexa |
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SDS siRNA |
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| 20-abx904833 | Abbexa |
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Nitromide |
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| 414420 | MedKoo Biosciences | 25.0g | 231 EUR |
Nitromide |
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| HY-B0945 | MedChemExpress | 100mg | 142.8 EUR |
Nitromide |
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| T0356-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Nitromide |
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Nitromide |
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| T0356-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Nitromide |
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Nitromide |
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| T0356-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Nitromide |
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Nitromide |
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| T0356-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Nitromide |
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Nitromide |
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| T0356-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Nitromide |
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Nitromide |
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| MBS3600819-100mg | MyBiosource | 100mg | 200 EUR |
Nitromide |
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| MBS3600819-200mg | MyBiosource | 200mg | 225 EUR |
Nitromide |
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| MBS3600819-5x200mg | MyBiosource | 5x200mg | 690 EUR |
Nitromide |
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| MBS576341-100mg | MyBiosource | 100mg | 145 EUR |
Nitromide |
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| MBS576341-200mg | MyBiosource | 200mg | 160 EUR |
Nitromide |
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| MBS576341-25mg | MyBiosource | 25mg | 120 EUR |
Nitromide |
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| MBS576341-50mg | MyBiosource | 50mg | 135 EUR |
Nitromide |
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| MBS576341-5x200mg | MyBiosource | 5x200mg | 570 EUR |
Sds (GFP-tagged) - Mouse serine dehydratase (Sds) |
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| MG204797 | Origene Technologies GmbH | 10 µg | Ask for price |
SDS (GFP-tagged) - Human serine dehydratase (SDS) |
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| RG217814 | Origene Technologies GmbH | 10 µg | Ask for price |
Sds (untagged) - Mouse serine dehydratase (Sds), (10ug) |
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| MC201984 | Origene Technologies GmbH | 10 µg | Ask for price |
SDS antibody |
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| 10R-5712 | Fitzgerald | 100 ul | 709 EUR |
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Description: Mouse monoclonal SDS antibody |
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SDS antibody |
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| 10R-5718 | Fitzgerald | 100 ul | 709 EUR |
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Description: Mouse monoclonal SDS antibody |
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SDS antibody |
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| 10R-5720 | Fitzgerald | 100 ul | 709 EUR |
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Description: Mouse monoclonal SDS antibody |
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SDS Solution |
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| 2102-100 | Biovision | each | 164.4 EUR |
SDS antibody |
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| 70R-3627 | Fitzgerald | 50 ug | 467 EUR |
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Description: Rabbit polyclonal SDS antibody raised against the N terminal of SDS |
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SDS antibody |
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| 70R-3762 | Fitzgerald | 50 ug | 467 EUR |
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Description: Rabbit polyclonal SDS antibody raised against the middle region of SDS |
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SDS Antibody |
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| GWB-MN886D | GenWay Biotech | 50ug | Ask for price |
SDS Antibody |
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| GWB-MN887E | GenWay Biotech | 50ug | Ask for price |
SDS antibody |
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| MBS833568-01mL | MyBiosource | 0.1mL | 1095 EUR |
SDS antibody |
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| MBS833568-5x01mL | MyBiosource | 5x0.1mL | 4770 EUR |
SDS antibody |
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| MBS833705-01mL | MyBiosource | 0.1mL | 1095 EUR |
SDS antibody |
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| MBS833705-5x01mL | MyBiosource | 5x0.1mL | 4770 EUR |
SDS antibody |
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| MBS834694-01mL | MyBiosource | 0.1mL | 1095 EUR |
SDS antibody |
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| MBS834694-5x01mL | MyBiosource | 5x0.1mL | 4770 EUR |
Nitromifene |
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| HY-100266 | MedChemExpress | 1mg | 1352.4 EUR |
Nitromifene |
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| N496703 | Toronto Research Chemicals | 25mg | 800 EUR |
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Description: 10448-84-7 |
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Nitromifene |
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| T16330-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Nitromifene |
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Nitromifene |
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| T16330-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Nitromifene |
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Nitromifene |
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| T16330-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Nitromifene |
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Nitromifene |
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| T16330-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Nitromifene |
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Nitromifene |
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| T16330-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Nitromifene |
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Nitromifene |
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| MBS3844862-10mg | MyBiosource | 10mg | 5025 EUR |
Nitromifene |
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| MBS3844862-1mg | MyBiosource | 1mg | 1035 EUR |
Nitromifene |
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| MBS3844862-5mg | MyBiosource | 5mg | 2970 EUR |
Nitromifene |
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| MBS3844862-5x10mg | MyBiosource | 5x10mg | 22595 EUR |
Nitromifene |
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| MBS5769693-5mg | MyBiosource | 5mg | 915 EUR |
Nitromifene |
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| MBS5769693-5x5mg | MyBiosource | 5x5mg | 3970 EUR |
Nitromazenil |
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| N496320 | Toronto Research Chemicals | 100mg | 1800 EUR |
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Description: 84377-97-9 |
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2-Nitromorphine |
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| N529990 | Toronto Research Chemicals | 10mg | 1162 EUR |
2-Nitro-m-xylene - 1ML |
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| S-2760 | Scientific Laboratory Supplies | 1ML | 51.3 EUR |
2-Nitro-m-toluic Acid |
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| N572300 | Toronto Research Chemicals | 100g | 190 EUR |
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Description: 5437-38-7 |
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Sds (Myc-DDK-tagged) - Mouse serine dehydratase (Sds) |
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| MR204797 | Origene Technologies GmbH | 10 µg | Ask for price |
SDS (Myc-DDK-tagged)-Human serine dehydratase (SDS) |
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| RC217814 | Origene Technologies GmbH | 10 µg | Ask for price |
Nitromifene Citrate |
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| 525760 | MedKoo Biosciences | 25.0mg | 500 EUR |
4-Nitromorpholine |
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| N496710 | Toronto Research Chemicals | 100mg | 604 EUR |
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Description: 4164-32-3 |
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Nitromifene Citrate |
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| T33688-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Nitromifene Citrate |
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Nitromifene Citrate |
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| T33688-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Nitromifene Citrate |
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Nitromifene Citrate |
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| T33688-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Nitromifene Citrate |
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Nitromifene Citrate |
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| T33688-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Nitromifene Citrate |
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Nitromifene Citrate |
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| T33688-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Nitromifene Citrate |
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Nitromifene Citrate |
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| MBS5783229-5mg | MyBiosource | 5(mg | 915 EUR |
Nitromifene Citrate |
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| MBS5783229-5x5mg | MyBiosource | 5x5(mg | 3970 EUR |
2-Nitro-m-toluic Acid-d3 |
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| N572302 | Toronto Research Chemicals | 750mg | 3000 EUR |
|
Description: 93457-59-1 |
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9-Nitrominocycline |
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| N888760 | Toronto Research Chemicals | 5mg | 800 EUR |
|
Description: 149934-16-7 |
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2-Nitro-m-xylene_x000D__x000D_ |
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| N13090 | Pfaltz & Bauer | 100G | 129.3 EUR |
Sds (untagged ORF) - Rat serine dehydratase (Sds), (10 ug) |
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| RN206422 | Origene Technologies GmbH | 10 µg | Ask for price |
Recombinant Petromyzon marinus Serum albumin SDS-1 (SDS-1), partial |
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| MBS1349557-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Xpert SDS Sample Buffer for SDS-PAGE(4X), Reducing |
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| X3500-050 | GenDepot | 50ml | 40 EUR |
Correspondence with PROUDs lead investigator also informed this letter. It was found that PROUD’s PPI improved study design, safety and advertising as well as providing reassurance in difficult times. It also improved recruitment, dissemination of information and made sure that results and future research fields were relevant. This allows us to understand and appreciate PPI‘s role in research and the provision of healthcare. It is also important to increase discussion and learning around PPI for the future.