RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

RNF43/ZNRF3 negatively regulates WNT signaling. Both genes are mutated in several types of cancers, however, their contribution to liver disease…

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LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2

In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) FAM181A-AS1 in human gliomas. TCGA, GTEx…

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An eQTL variant of ZXDC is associated with IFN-γ production following Mycobacterium tuberculosis antigen-specific stimulation.

There is a large inter-individual variability in the response to Mycobacterium tuberculosis infection. In previous linkage analyses, we identified a…

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Recombinant Unique Cartilage Matrix-associated Protein Potentiates Osteogenic Differentiation and Mineralization of MC3T3-E1 Cells

Objective: The relative balance of osteoblasts in bone formation and osteoclasts in bone resorption is crucial for maintaining bone health. With…

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HIV Genome-Wide Protein Associations: a Review of 30 Years of Research.

The HIV genome encodes a small quantity of viral proteins (i.e., 16), invariably establishing cooperative associations amongst HIV proteins and…

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Establishing the Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CHIWOS): Operationalizing Community-based Research in a Large National Quantitative Study.

Community-based research has gained increasing recognition in health research over the last two decades. Such participatory research approaches are lauded…

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Single-Cell Technologies Applied to HIV-1 Research: Reaching Maturity.

The want for definitive solutions in all probability explains our pure tendency to search simplicity. The reductionist “bulk” strategy, through…

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