Status of vaccine research and development of vaccines for HIV-1.
Human immunodeficiency virus (HIV) is the cause of one of the most lethal pandemics in human history, although in recent years access to highly effective anti-retroviral therapy has provided new hope worldwide. Transmission of HIV by sexual contact, childbirth and injection drug use has been reduced, but 2 million are newly infected each year, and much of the transmission is from people who do not know their status. In addition to known methods, a preventive vaccine is needed to end the pandemic.
Nitroblue tetrazolium chloride |
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GC4263-5G | Glentham Life Sciences | 5 g | 265.2 EUR |
Nitroblue tetrazolium chloride |
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GC4263-1 | Glentham Life Sciences | 1 | 71.1 EUR |
Nitroblue tetrazolium chloride |
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GC4263-5 | Glentham Life Sciences | 5 | 189.8 EUR |
Nitroblue tetrazolium chloride |
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GC4263-500 | Glentham Life Sciences | 500 | 45.1 EUR |
NITRO BLUE TETRAZOLIUM |
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N602 | PhytoTechnology Laboratories | 100MG | 101.87 EUR |
Nitro Blue Tetrazolium |
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24720-01 | NACALAI TESQUE | 1G | 74.2 EUR |
Nitro Blue Tetrazolium |
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24720-14 | NACALAI TESQUE | 5G | 244.3 EUR |
Nitro Blue Tetrazolium |
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24720-56 | NACALAI TESQUE | 100MG | 15.75 EUR |
Nitro blue tetrazolium chloride |
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HY-15925 | MedChemExpress | 250mg | 142.8 EUR |
Nitro blue tetrazolium chloride |
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T19032-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nitro blue tetrazolium chloride |
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Nitro blue tetrazolium chloride |
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T19032-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nitro blue tetrazolium chloride |
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Nitro blue tetrazolium chloride |
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T19032-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nitro blue tetrazolium chloride |
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Nitro blue tetrazolium chloride |
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T19032-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nitro blue tetrazolium chloride |
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Nitro blue tetrazolium chloride |
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T19032-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nitro blue tetrazolium chloride |
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NBT (nitro blue tetrazolium, chloride) |
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10008 | Biotium | 250MG | 109.2 EUR |
Description: Minimum order quantity: 1 unit of 250MG |
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NBT (nitro blue tetrazolium, chloride) |
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10008-1 | Biotium | 1G | 213.6 EUR |
Description: Minimum order quantity: 1 unit of 1G |
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NBT (nitro blue tetrazolium, chloride) |
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10008-2 | Biotium | 5G | 663.6 EUR |
Description: Minimum order quantity: 1 unit of 5G |
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Nitro Blue Tetrazolium Chloride [NBT] |
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A4120-1G | Biomatik Corporation | 1G | 90.2 EUR |
Description: Biotechnology |
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Nitro Blue Tetrazolium Chloride [NBT] |
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A4120-250MG | Biomatik Corporation | 250MG | 30.8 EUR |
Description: Biotechnology |
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Nitro Blue Tetrazolium Chloride [NBT] |
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A4120-500MG | Biomatik Corporation | 500MG | 50.6 EUR |
Description: Biotechnology |
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NBT (Nitro Blue Tetrazolium, Chloride), 1 g |
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10008-1-1 | Biotium | EA | 156 EUR |
NBT (Nitro Blue Tetrazolium, Chloride), 5 g |
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10008-2-1 | Biotium | EA | 606 EUR |
Nitro blue tetrazolium chloride monohydrate |
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20-abx184281 | Abbexa |
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Tetrazolium Red |
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HY-D0714 | MedChemExpress | 500mg | 129.6 EUR |
Tetrazolium Red |
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T19577-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Tetrazolium Red |
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Tetrazolium Red |
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T19577-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Tetrazolium Red |
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Tetrazolium Red |
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T19577-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Tetrazolium Red |
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Tetrazolium Red |
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T19577-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Tetrazolium Red |
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Tetrazolium Red |
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T19577-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Tetrazolium Red |
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Blue Tetrazolium |
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05107-41 | NACALAI TESQUE | 1G | 36.4 EUR |
Blue Tetrazolium |
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B17093 | Pfaltz & Bauer | 1G | 156.93 EUR |
Tetrazolium Violet |
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GT6818-10G | Glentham Life Sciences | 10 g | 351.6 EUR |
Tetrazolium Violet |
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GT6818-1G | Glentham Life Sciences | 1 g | 84 EUR |
Tetrazolium Violet |
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GT6818-5G | Glentham Life Sciences | 5 g | 204 EUR |
Tetrazolium Violet |
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GT6818-1 | Glentham Life Sciences | 1 | 39.4 EUR |
Tetrazolium Violet |
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GT6818-10 | Glentham Life Sciences | 10 | 261 EUR |
Tetrazolium Violet |
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GT6818-5 | Glentham Life Sciences | 5 | 138.5 EUR |
Tetrazolium Violet_x000D__x000D_ |
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T08980 | Pfaltz & Bauer | 10G | 364.48 EUR |
Tetrazolium Blue Chloride |
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GT7170-1G | Glentham Life Sciences | 1 g | 84 EUR |
Tetrazolium Blue Chloride |
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GT7170-5G | Glentham Life Sciences | 5 g | 180 EUR |
Tetrazolium Blue Chloride |
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GT7170-1 | Glentham Life Sciences | 1 | 39.4 EUR |
Tetrazolium Blue Chloride |
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GT7170-5 | Glentham Life Sciences | 5 | 118.7 EUR |
TETRAZOLIUM BLUE CHLORIDE |
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T8199 | PhytoTechnology Laboratories | 1G | 101.87 EUR |
Methylthialazole Tetrazolium |
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330214 | MedKoo Biosciences | 1.0g | 250 EUR |
TRIPHENYL TETRAZOLIUM CHLORIDE |
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T8164 | PhytoTechnology Laboratories | 100G | 24.14 EUR |
Tetranitroblue tetrazolium chloride |
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GK5496-100MG | Glentham Life Sciences | 100 mg | 76.8 EUR |
Tetranitroblue tetrazolium chloride |
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GK5496-1G | Glentham Life Sciences | 1 g | 284.4 EUR |
Tetranitroblue tetrazolium chloride |
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GK5496-1 | Glentham Life Sciences | 1 | 205.7 EUR |
Tetranitroblue tetrazolium chloride |
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GK5496-100 | Glentham Life Sciences | 100 | 34.1 EUR |
Tetranitro Blue tetrazolium chloride |
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T08200 | Pfaltz & Bauer | 500MG | 453 EUR |
Thiazolyl Blue Tetrazolium Bromide |
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abx188911-50g | Abbexa | 50 g | 927.6 EUR |
Thiazolyl Blue Tetrazolium Bromide |
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20-abx082213 | Abbexa |
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Thiazolyl Blue Tetrazolium Bromide |
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20-abx082549 | Abbexa |
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Thiazolyl blue tetrazolium bromide |
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GC4568-10G | Glentham Life Sciences | 10 g | 208.8 EUR |
Thiazolyl blue tetrazolium bromide |
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GC4568-1G | Glentham Life Sciences | 1 g | 74.4 EUR |
Thiazolyl blue tetrazolium bromide |
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GC4568-5G | Glentham Life Sciences | 5 g | 132 EUR |
Thiazolyl blue tetrazolium bromide |
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GC4568-1 | Glentham Life Sciences | 1 | 31.7 EUR |
Thiazolyl blue tetrazolium bromide |
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GC4568-10 | Glentham Life Sciences | 10 | 142.4 EUR |
Thiazolyl blue tetrazolium bromide |
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GC4568-5 | Glentham Life Sciences | 5 | 79.1 EUR |
Tetranitroblue tetrazolium chloride (TNBT) |
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T6756 | Bio Basic | 250mg | 99.67 EUR |
Cyanoditolyl Tetrazolium Chloride (CTC) |
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19292-1 | Polysciences Europe GmbH | 1g | 1358 EUR |
Description: 102568-47-8 |
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Cyanoditolyl Tetrazolium Chloride (CTC) |
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19292-100 | Polysciences Europe GmbH | 100mg | 198 EUR |
Description: 102568-47-8 |
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Thiazolyl Blue tetrazolium bromide 98% |
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T09850 | Pfaltz & Bauer | 1G | 122.03 EUR |
Thiazolyl Blue Tetrazolium Bromide [MTT) |
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A3338-1G | Biomatik Corporation | 1G | 49.5 EUR |
Description: Ultra Pure |
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Thiazolyl Blue Tetrazolium Bromide [MTT) |
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A3338-250MG | Biomatik Corporation | 250MG | 22 EUR |
Description: Ultra Pure |
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Thiazolyl Blue Tetrazolium Bromide [MTT) |
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A3338-5G | Biomatik Corporation | 5G | 180.4 EUR |
Description: Ultra Pure |
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Thiazolyl blue tetrazolium bromide (MTT) |
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T0793 | Bio Basic | 500mg | 86.1 EUR |
CTC (5-Cyano-2, 3-ditolyl tetrazolium chloride) |
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10063 | Biotium | 10MG | 121.2 EUR |
Description: Minimum order quantity: 1 unit of 10MG |
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CTC (5-Cyano-2, 3-ditolyl tetrazolium chloride) |
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10063-1 | Biotium | EA | 62 EUR |
2 5-Diphenyl-3-(4-Styrylphenyl)tetrazolium Chloride_x000D_ |
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D52320 | Pfaltz & Bauer | 100MG | 213.78 EUR |
(RS)-(Tetrazol-5-yl)glycine |
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B6254-10 | ApexBio | 10 mg | 459.6 EUR |
(RS)-(Tetrazol-5-yl)glycine |
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B6254-50 | ApexBio | 50 mg | 1746 EUR |
(RS)-(Tetrazol-5-yl)glycine |
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T16801-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: (RS)-(Tetrazol-5-yl)glycine |
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(RS)-(Tetrazol-5-yl)glycine |
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T16801-1g | TargetMol Chemicals | 1g | Ask for price |
Description: (RS)-(Tetrazol-5-yl)glycine |
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(RS)-(Tetrazol-5-yl)glycine |
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T16801-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: (RS)-(Tetrazol-5-yl)glycine |
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(RS)-(Tetrazol-5-yl)glycine |
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T16801-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: (RS)-(Tetrazol-5-yl)glycine |
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(RS)-(Tetrazol-5-yl)glycine |
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T16801-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: (RS)-(Tetrazol-5-yl)glycine |
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Tetrazole |
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abx089253-100ml | Abbexa | 100 ml | 393.6 EUR |
Tetrazole |
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A7061-100000 | ApexBio | 100 g | 211.2 EUR |
Description: IC50: Not available.Tetrazole is the simplest compound belonging to tetrazoles family, a class of synthetic organic heterocyclic compound consists of a 5-member ring of four nitrogen and one carbon atom. |
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Tetrazole |
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A7061-25000 | ApexBio | 25 g | 110.4 EUR |
Description: IC50: Not available.Tetrazole is the simplest compound belonging to tetrazoles family, a class of synthetic organic heterocyclic compound consists of a 5-member ring of four nitrogen and one carbon atom. |
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Tetrazole |
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T8520-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Tetrazole |
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Tetrazole |
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T8520-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Tetrazole |
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Tetrazole |
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T8520-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Tetrazole |
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Tetrazole |
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T8520-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Tetrazole |
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Tetrazole |
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T8520-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Tetrazole |
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5-Methyl tetrazole |
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20-abx183745 | Abbexa |
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5-Ethylthio-1(H)-tetrazole |
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GE7013-1G | Glentham Life Sciences | 1 g | 54 EUR |
5-Ethylthio-1(H)-tetrazole |
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GE7013-25G | Glentham Life Sciences | 25 g | 180 EUR |
5-Ethylthio-1(H)-tetrazole |
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GE7013-5G | Glentham Life Sciences | 5 g | 84 EUR |
Tetrazole-1-acetic acid |
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GE9742-1G | Glentham Life Sciences | 1 g | 69.6 EUR |
Tetrazole-1-acetic acid |
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GE9742-5G | Glentham Life Sciences | 5 g | 126 EUR |
42-(2-Tetrazolyl)rapamycin |
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HY-12424A | MedChemExpress | 1mg | 241.2 EUR |
42-(2-Tetrazolyl)rapamycin |
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T10158-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: 42-(2-Tetrazolyl)rapamycin |
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42-(2-Tetrazolyl)rapamycin |
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T10158-1g | TargetMol Chemicals | 1g | Ask for price |
Description: 42-(2-Tetrazolyl)rapamycin |
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42-(2-Tetrazolyl)rapamycin |
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T10158-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: 42-(2-Tetrazolyl)rapamycin |
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42-(2-Tetrazolyl)rapamycin |
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T10158-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: 42-(2-Tetrazolyl)rapamycin |
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42-(2-Tetrazolyl)rapamycin |
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T10158-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: 42-(2-Tetrazolyl)rapamycin |
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5-Ethylthio-1(H)-tetrazole |
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GE7013-1 | Glentham Life Sciences | 1 | 16.4 EUR |
5-Ethylthio-1(H)-tetrazole |
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GE7013-25 | Glentham Life Sciences | 25 | 118.7 EUR |
5-Ethylthio-1(H)-tetrazole |
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GE7013-5 | Glentham Life Sciences | 5 | 39.4 EUR |
5-Amino-1(H)-tetrazole hydrate |
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GK3683-100G | Glentham Life Sciences | 100 g | 124.8 EUR |
5-Amino-1(H)-tetrazole hydrate |
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GK3683-250G | Glentham Life Sciences | 250 g | 212.4 EUR |
5-Amino-1(H)-tetrazole hydrate |
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GK3683-25G | Glentham Life Sciences | 25 g | 70.8 EUR |
5-Amino-1(H)-tetrazole hydrate |
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GK3683-500G | Glentham Life Sciences | 500 g | 342 EUR |
5-Amino-1(H)-tetrazole hydrate |
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GK3683-100 | Glentham Life Sciences | 100 | 73.5 EUR |
5-Amino-1(H)-tetrazole hydrate |
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GK3683-25 | Glentham Life Sciences | 25 | 29.2 EUR |
5-Amino-1(H)-tetrazole hydrate |
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GK3683-250 | Glentham Life Sciences | 250 | 145.5 EUR |
5-Amino-1(H)-tetrazole hydrate |
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GK3683-500 | Glentham Life Sciences | 500 | 253.1 EUR |
5-Mercapto-1-phenyl-1,2,3,4-tetrazole 99% |
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M03850 | Pfaltz & Bauer | 5G | 118.34 EUR |
5-bromo-N-methyl-N-(1-methyl-1H-1,2,3,4-tetrazol-5-yl)pyridi |
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20-abx185265 | Abbexa |
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N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)tetrazole |
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20-abx181327 | Abbexa |
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(R)-nitro-Blebbistatin |
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T35458-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: (R)-nitro-Blebbistatin |
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(R)-nitro-Blebbistatin |
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T35458-1g | TargetMol Chemicals | 1g | Ask for price |
Description: (R)-nitro-Blebbistatin |
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(R)-nitro-Blebbistatin |
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T35458-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: (R)-nitro-Blebbistatin |
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(R)-nitro-Blebbistatin |
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T35458-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: (R)-nitro-Blebbistatin |
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(R)-nitro-Blebbistatin |
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T35458-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: (R)-nitro-Blebbistatin |
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(S)-nitro-Blebbistatin |
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T36335-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: (S)-nitro-Blebbistatin |
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(S)-nitro-Blebbistatin |
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T36335-1g | TargetMol Chemicals | 1g | Ask for price |
Description: (S)-nitro-Blebbistatin |
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(S)-nitro-Blebbistatin |
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T36335-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: (S)-nitro-Blebbistatin |
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(S)-nitro-Blebbistatin |
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T36335-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: (S)-nitro-Blebbistatin |
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(S)-nitro-Blebbistatin |
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T36335-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: (S)-nitro-Blebbistatin |
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Nitronium tetrafluoroborate 96% |
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N10210 | Pfaltz & Bauer | 5G | 264.38 EUR |
Nitronium tetrafluoroborate 0.5M Soln. in sulfolane |
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N10220 | Pfaltz & Bauer | 25ML | 377.2 EUR |
2,3,4,6-Tetra-O-(3-nitropropanoyl) -α-D-glucopyranose |
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TTE1357 | ChemNorm | 5mg | Ask for price |
3-Nitro-4-((tetrahydro-2h-pyran-4-yl)methylamino)benzenesulfonamide |
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20-abx184585 | Abbexa |
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Nitrobenzene 99% |
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N06760 | Pfaltz & Bauer | 1KG | 342.2 EUR |
1-Nitrobutane 97% |
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N07760 | Pfaltz & Bauer | 5G | 766.26 EUR |
Nitrobenzene |
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S-2705 | Scientific Laboratory Supplies | 1ML | 45.6 EUR |
Nitrobenzene |
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24609-65 | NACALAI TESQUE | 500ML | 12.6 EUR |
Nitrobenzene |
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24610-25 | NACALAI TESQUE | 500ML | 15.05 EUR |
4-Nitrobiphenyl |
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20-abx181185 | Abbexa |
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3-nitrobiphenyl |
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abx186279-25g | Abbexa | 25 g | 577.2 EUR |
2-Nitrobiphenyl |
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N07630 | Pfaltz & Bauer | 25G | 442.98 EUR |
3-Nitrobiphenyl 95% |
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N07640 | Pfaltz & Bauer | 5G | 438.12 EUR |
Nitrobenzene-d5 |
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S-2710 | Scientific Laboratory Supplies | 1ML | 84 EUR |
3'-O-(2-nitrobenzyl)-2'-dATP |
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B8123-.01 | ApexBio | 10ul (100 mM) | 181 EUR |
3'-O-(2-nitrobenzyl)-2'-dATP |
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B8123-.05 | ApexBio | 50ul (100 mM) | 838 EUR |
3'-O-(2-nitrobenzyl)-2'-dATP |
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B8123-.1 | ApexBio | 100ul (100 mM) | 1535 EUR |
3'-O-(2-nitrobenzyl)-2'-dITP |
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B8124-.01 | ApexBio | 10ul (100 mM) | 181 EUR |
3'-O-(2-nitrobenzyl)-2'-dITP |
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B8124-.05 | ApexBio | 50ul (100 mM) | 838 EUR |
3'-O-(2-nitrobenzyl)-2'-dITP |
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B8124-.1 | ApexBio | 100ul (100 mM) | 1535 EUR |
4-Nitrobenzamide |
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20-abx183634 | Abbexa |
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Nitrobenzene-HRP |
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80-1230 | Fitzgerald | 500 ul | 970.8 EUR |
Description: Nitrobenzene Conjugate for use in immunoassays |
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4-Nitrobenzoic acid |
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GK5397-25G | Glentham Life Sciences | 25 g | 52.8 EUR |
4-Nitrobenzoic acid |
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T20882-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: 4-Nitrobenzoic acid |
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4-Nitrobenzoic acid |
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T20882-1g | TargetMol Chemicals | 1g | Ask for price |
Description: 4-Nitrobenzoic acid |
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4-Nitrobenzoic acid |
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T20882-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: 4-Nitrobenzoic acid |
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4-Nitrobenzoic acid |
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T20882-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: 4-Nitrobenzoic acid |
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4-Nitrobenzoic acid |
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T20882-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: 4-Nitrobenzoic acid |
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VOC Nitrobenzene Neat |
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REVOC380N | Scientific Laboratory Supplies | 10MG | 46.87 EUR |
The extraordinary mutability and genetic diversity of HIV is an enormous challenge, but vaccines are being designed for broad coverage. Computer-aided design of mosaic immunogens, incorporating many epitopes from the entire genome or from conserved regions aim to induce CD8+ T cells to kill virus-infected cells or inhibit virus replication, while trimeric envelope proteins or synthetic mimics aim to induce broadly reactive neutralizing antibodies similar to those cloned from some infected patients.
Induction of more potent and durable responses may require new adjuvants or replicating chimeric vectors chimeras that bear HIV genes. Passive or genetic delivery of broadly neutralizing antibodies may provide broad protection and/or lead to insights for vaccine designers. Proof-of-concept trials in non-human primates and in one human efficacy trial have provided scientific clues for a vaccine that could provide broad and durable protection against HIV. The use of vaccines to destroy HIV reservoirs as part of therapy or cure is now also being explored.